Fragile X Syndrome

slender X syndrome is the or so common divisortically contractable noetic strain of mental interim currently known. In addition to reason disability, some(prenominal) one-on-ones with Fragile X demonstrate common carnal traits and sign facial features, such as prominent ears. Children with Fragile X often appear shape in babyhood only develop common forcible characteristics during their lifetime. Mental injury whitethorn range from mild breeding disability and hyperactivity to gross(a) mental retardation and autism. This divisortic syndrome is caused by an magnification of iterate segment of FMR-1 gene on X chromosome. Because of scientific advances, improvements in genetic testing, and revision magnitude awargonness, the telephone form of children diagnosed with Fragile X has addd significantly over the last ten (Stephen and Allan, 2000). Although the common spot of the FMR-1 gene is not fully understood, it appears to be important premature in development. The mechanism by which the normal FMR-1 gene is reborn into an altered, or mutant, gene capable of causing disease symptoms involves an increase in the distance of the gene. At the 5 neighbourhood of the FMR-1 gene, the CGG nucleotide rank undergoes tell duplications, forming deoxyribonucleic acid (desoxyribonucleic acid) repeats that result in a longitudinal gene. The drawn-out DNA region is unvaccinated to a chemical total modification process called DNA methylation.

When the snatch of repeats is small (usually from 50-200), as in the grimace of premutation, the individual often has no signs of the disorder. However, in individuals with a larger list of repeats (more than 200), as in the character of full mutation, the characteristics that atomic number 18 typical of Fragile X are observed (Stephen and Allan, 2000; Frank, 2000). In families that record Fragile X, both the number of repeats and the continuance of the chromosome increase with win generations. The severity of the symptoms increases with the increasing length of the... If you want to get a full essay, order it on our website: Ordercustompaper.com

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